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Mesothelioma - What Causes Mesothelioma?

Like all cancers, mesothelioma is difficult to diagnose because its symptoms may resemble other diseases. However the early diagnosis and treatment can improve a patient's prognosis.

Asbestos is the most significant reason for mesothelioma. Asbestos is made up of a group minerals that can be separated into long, thin fibres. Asbestos fibres can become stuck in certain organs when inhaled or consumed.

Exposure to Asbestos

The most well-known mesothelioma-related cause is exposure to asbestos. Asbestos is an naturally occurring mineral that is composed of microscopic, strong fibers. It was used extensively in vehicles, buildings and a variety of construction equipment from the 1930s until the early 1980s because it was resistant to fire, water and sound. The makers of asbestos-based materials were aware of the dangers it poses to health, yet they did not inform the public.

Workers who directly handled asbestos or handled products made of it were most at danger of exposure. Mining ships, asbestos removal and other industrial jobs exposed workers amounts of asbestos. Workers also came into contact with asbestos to asbestos-containing products, including shingles, pipes, glues, and talcum powder. In the United States, chrysotile asbestos is most commonly employed. Other asbestos types such as amosite or crocidolite are also linked to mesothelioma.

Mesothelioma symptoms typically do not manifest until years after exposure to asbestos. When they do, the condition can grow rapidly and eventually can even become fatal. The most common affliction is the lung (pleural mesothelioma) but can occur in the stomach's lining or the testicles.

Asbestos fibers that are inhaled or ingestion stick to the cells that line the internal organs and tissues. This causes genetic mutations that can lead to cancer. The cancerous cells expand uncontrollably, and eventually form tumors.

People who work in industries with a high exposure to asbestos are at an increased risk of developing mesothelioma than those who do not. The most at risk are men who had blue-collar jobs or served in the military. But mesothelioma is a possibility in women who were exposed to asbestos, in particular in the case of relatives who were exposed to asbestos while at work.

Secondary exposure can happen when someone who is at risk of mesothelioma wears asbestos fibres on their clothes and other clothing. This has occurred to spouses of asbestos-exposed people and also to some tile and hairdressers. Some studies have shown that a mineral called Erionite, a mineral that is similar to asbestos, increases the chance of developing mesothelioma. However, this has not yet been confirmed by other studies.

Exposure to Minerals

Mesothelioma results from the transformation of cells that line specific areas of the body, including the lining of the chest (pleura) and abdominal cavities. Mesothelioma can also affect the heart's lining (pericardium) or testicles (tunica vaginalis). The disease is most commonly associated with exposure to asbestos, however there are other causes.

Asbestos is a mineral that occurs naturally composed of strong and microscopic fibers. It was used for building material, in the manufacture of automobile brakes and for a range of other products in the 1930s and 1980s, because it was resistant to fire, water and sound. A lot of people working employed in the construction industry or military were exposed. Workers who remove and handle asbestos are at a higher risk of breathing in dangerous particles.


The specific risk of mesothelioma is different based on the work environment however any exposure to asbestos increases the chance of developing the illness. Mesothelioma has been linked to a variety of industries and occupations but, in the majority of cases, it is seen in miners, millers, shipyard workers and asbestos producers. It has been identified in those who work in the production line of automobiles and aircrafts and also in those who handle or sand insulation.

Mesothelioma typically develops slowly, however symptoms can occur between 20 and 60 years after asbestos exposure. It is essential for everyone to speak to a doctor about mesothelioma, even if they've not been exposed to asbestos before. The earlier cancer is detected the more likely it will be to treat it successfully.

In mesothelioma is a cancer caused by what , mesothelioma was not diagnosed until it had advanced. Mesothelioma is a rare kind of cancer, so doctors may overlook symptoms such as a persistent cough or breathing difficulties.

Asbestos was phased out by the 1980s. However those who worked in the military and in the industrial industry prior to that time are still at risk of mesothelioma. Researchers have recently discovered new types of mineral exposure which increase the risk of mesothelioma. For example, a mineral called erionite is found in the soil of a few regions of Turkey and is used to make the materials in the area. In studies of the local population that is exposed to erionite extensively the risk for men is higher than women to develop mesothelioma. In Italy, the same thing has been observed in relation to a different mineral called fluoroedenite.

Genetics

Mesothelioma is a form of cancer that affects the mesothelium. It is most commonly found in the chest cavity's lining (pleura), but it can also affect tissues around the abdomen, heart and testicles.

Doctors have linked mesothelioma with a gene mutation known as BAP1. This gene regulates a process that puts calcium inside cells, and when it is altered the person is more likely to develop cancerous cells. Researchers have discovered that BAP1 mutants are found in 70 percent of patients with mesothelioma. This discovery has made mesothelioma more easy to diagnose and increased screening, particularly for people with an ancestral history.

In addition to BAP1, researchers have identified various other genetic mutations that could cause mesothelioma. These mutations have also helped mesothelioma experts gain a better understanding of the disease and how to manage it.

While genetics influence mesothelioma, asbestos is still the leading risk factor for the cancer. Some people exposed to asbestos don't develop cancer, but others with no genetic predisposition may develop mesothelioma after a long period of exposure. Secondary exposure, also known as paraoccupational exposure, can be triggered when asbestos-exposed coworkers bring home fibers that are absorbed into their clothing and skin.

In some instances mesothelioma is seen to run in families because of a combination of genetics and asbestos exposure. However, the majority of mesothelioma cases are random and do not seem to have any family history of the disease.

Asbestos-related mesothelioma is a severe and complicated disease, but research continues to make incredible advancements in the treatment and recovery options for patients. Asbestos is now banned in a number of countries around the world, and scientists are improving mesothelioma treatments by utilizing better drugs, more targeted surgeries and more efficient diagnostic tests. Download a free copy our Mesothelioma Guide to learn about how these recent advancements could benefit you. This comprehensive resource contains the complete list of mesothelioma treatment options, including the most recent clinical trials and promising alternatives. Download the guide by filling in our online form or calling directly.

Lifestyle

Mesothelioma affects the cells that line certain parts of the human body, including the lungs and abdomen. Most cases of mesothelioma start in the chest cavity's lining (the pleura) but it can be found in the abdomen's lining (the peritoneum) and around the heart (the pericardium).

While asbestos exposure is a major risk factor however other factors like gender and age can also increase the likelihood of developing mesothelioma. Certain of these factors such as smoking or a person's gender can be altered, whereas others, like the age of the person or their family history are not.

Most mesothelioma patients are related to someone else who has the disease and who has been exposed to asbestos for a long time. Most people diagnosed with peritoneal or pleural cancer are older than 45. This is because mesothelioma takes years to develop, and the symptoms can start to manifest as an individual ages.

A biopsy is one of the tests doctors use to detect pleural mesothelioma. Other tests include the CT scan, FDG-positron emission tomography and a CT scan. A biopsy is the process of removing some of the tissue for examination under a microscope, and can be done by using VATS (Video-assisted surgery using thoracoscopic instruments) it is a type of keyhole operation; or a needle guided by an CT scan.

Doctors can also test a patient's blood for a genetic mutation known as BAP1. This is an alteration in the gene that suppresses the growth of tumors and makes a person more prone to developing malignancies caused by environmental contaminants. People who have this mutation are more likely to develop mesothelioma when they have experienced relatively low levels of asbestos exposure. Additionally, they have less time to develop the disease than those without the genetic mutation. However, researchers don't yet know how common this mutation is in the general population, or whether it can be cured by lifestyle choices like avoiding exposure to harmful substances. This is an area of ongoing research.

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