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Mesothelioma - What Causes Mesothelioma?

Like all cancers, mesothelioma can be difficult to diagnose because its symptoms may resemble other diseases. However, early diagnosis and treatment can greatly improve the chances of survival for patients.

Asbestos exposure is the primary reason for mesothelioma. Asbestos is a class of minerals that are able to break down into long, thin fibers. When inhaled or consumed asbestos fibers can be trapped in the lining of certain organs.

Exposure to Asbestos

The exposure to asbestos is the most confirmed cause of Mesothelioma. Asbestos is a mineral that occurs naturally is composed of tough and microscopic fibers. It was used extensively in automobiles, buildings, and a myriad of construction materials in the 1930s through the early 1980s because it resisted fire, water and sound. The producers of asbestos-based materials were aware that it was harmful to health, yet they did not inform the public.

The greatest exposure risk was for those who directly handled asbestos products. People working in mining of asbestos, shipbuilding, asbestos removal and other industrial jobs were exposed to large quantities of asbestos. The workers also had to be exposed through home use of asbestos-containing products, including shingles, pipes, glues, and talcum powder. In the United States, chrysotile asbestos is the most popular type of asbestos used. Other asbestos types such as amosite or Crocidolite have also been associated with mesothelioma.

The symptoms of mesothelioma typically don't show up until decades after asbestos exposure. Once they do, the condition can progress rapidly and can even become fatal. The lungs are the ones most commonly affected (pleural mesothelioma) However, it can also affect the stomach lining or the heart, as well as your testicles.

When asbestos fibres are inhaled or swallowed, they stick to cells that connect the body's organs and tissues. This triggers genetic mutations that result in cancer. The mutated cells grow uncontrollably and develop tumors.

Workers in industries that are exposed to asbestos more often are at a greater risk of developing mesothelioma. The most at risk are those who held blue-collar jobs or were in the military. Women who were exposed to asbestos may develop mesothelioma. This is especially true if their family members were exposed while at work.

Secondary exposure can happen when someone at risk of mesothelioma wears asbestos fibres on their clothes and clothes. This has occurred to spouses of asbestos-exposed individuals and also to some hairdressers and tile workers. Some studies have revealed that a mineral known as Erionite, a mineral that is similar to asbestos, increases the risk of developing mesothelioma. However this hasn't yet been confirmed by other studies.

Exposure to minerals

Mesothelioma develops from the transformation of cells that line particular parts of the body, including the chest lining (pleura) and abdominal cavities. Mesothelioma may also develop in the linings of the heart (pericardium), or testicles. The condition is usually associated with asbestos exposure, however, other causes could be responsible.

Asbestos is a naturally occurring mineral that is composed of strong microscopic fibers. It was used for building material, in brakes for automobiles and for a range of other products in the 1930s and 1980s, because it was resistant to water, fire, and sound. Many people in the construction industry or in the military were exposed. Workers who remove and handle asbestos are at greater risk of inhaling the harmful particles.


Although the exact mesothelioma risk is dependent on the job, any asbestos exposure can increase a person's likelihood of developing the disease. Mesothelioma has been linked to all sorts of occupations and industries but, in the majority of cases, it is found in millers, miners, shipyard workers and asbestos manufacturers. It has been found in those who work on the production line of automobiles and aircrafts, as well as those who handle or sand insulation.

The onset of mesothelioma generally slow, however it could take anywhere from 20 to 60 years for symptoms to appear after asbestos exposure. It is crucial that everyone consult an expert on mesothelioma even if they've not been exposed to asbestos. The earlier the cancer is discovered the simpler it will be to treat.

In the past, mesothelioma was not diagnosed until it had progressed. Since mesothelioma cancer is extremely rare doctors often ignore symptoms like persistent coughing and difficulty breathing.

Asbestos usage was largely eliminated in the 1980s, but those who were in the military or worked in industrial positions before that time are still at a greater risk of developing mesothelioma. Researchers have recently discovered new kinds of exposure to minerals that increase mesothelioma risk. In Turkey, for example the mineral known as Erionite is found in the soil and used to make materials. Studies of the local population that is exposed to a lot of erionite have discovered that men in these communities are more likely to develop mesothelioma more than women. Similar findings have been found with a different mineral called fluoro-edenite, which is found in Italy.

Genetics

The mesothelium is affected by this type of cancer. It is most commonly located in the lining of the chest cavity, but can also affect the tissue around the abdomen, heart and testicles.

Doctors have linked the mesothelioma with a gene mutation known as BAP1. This gene controls the process that releases calcium into cells. If it is altered, the person is at a greater risk chance of developing cancerous cells. Scientists have found that BAP1 mutations are present in 70 percent of patients who suffer from mesothelioma. This discovery has made mesothelioma easier to recognize and has led to increased screening, particularly for people with family history.

In addition to BAP1, researchers have identified various other genetic mutations that may lead to mesothelioma. These mutations also helped mesothelioma experts better understand the disease, and manage it.

Asbestos is the most significant risk factor in mesothelioma. Genetics also play a role. Certain asbestos-exposure victims do not develop cancer however others who do not have a genetic predisposition could develop mesothelioma over a long time. mesothelioma caused by asbestos or paraoccupational asbestos exposure can be a result of coworkers who have been exposed to asbestos bring fibers to their clothing and skin.

In some cases mesothelioma is seen to run in families due to the combination of genetics and asbestos exposure. Mesothelioma seems to be a random disease and does not appear to have an ancestral history.

Asbestos related mesothelioma can be a serious illness. However research is continuing to make significant improvements in the treatment of patients and their options for recovery. Asbestos is now banned in a number of countries across the globe and researchers are advancing mesothelioma treatment options by using better drugs, more specific surgeries, and more efficient diagnostic tests. To find out more about the latest developments you can request a copy of the Mesothelioma Guide. This comprehensive guide contains an extensive list of treatments for mesothelioma that include the most up-to-date clinical trials and promising alternative therapies. The guide is available for download by completing our short, online form or calling us directly.

Lifestyle

Mesothelioma affects the cells that line specific parts of the human body, such as the abdomen and lungs. The majority of mesothelioma cases begin in the lining of the chest cavity (the pleura), but it can be found in the abdomen's lining (the peritoneum) and around the heart (the pericardium).

While asbestos exposure is a primary risk factor, other factors such as gender or age can increase the risk of developing mesothelioma. Some of these risk factors, like smoking or a person’s gender can change, whereas others, such as the age of the person or their family history are not.

Most mesothelioma patients have an ancestral history of the disease, and many experienced long-term exposure to asbestos in their jobs. Patients diagnosed with pleural mesothelioma are typically over 45 years old, and the majority of patients suffering from mesothelioma of the peritoneal region are older than 65. This is due to the fact that mesothelioma can take years to develop, and the symptoms can begin to show up in an older person gets older.

There are several tests that doctors employ to detect mesothelioma including the use of a CT scan (computerised tomography), FDG-positron emission tomography (a test that utilizes a radioactive substance to look at how the tumour is growing) and biopsy. A biopsy is the process of removing the tissue for examination under a microscope. It can be done using VATS (Video-assisted thoracoscopic surgery) which is a kind of keyhole operation or a needle that is guided by a CT scan.

Doctors are also able to test a person's blood for a genetic defect called BAP1. This is a mutation in the gene that inhibits the growth of tumours and makes someone more prone to developing malignancies caused by environmental toxins. This mutation increases the chance of developing mesothelioma in the case of relatively low levels of asbestos exposure. It also decreases the time to develop mesothelioma for those with this mutation. Researchers aren't sure how prevalent this mutation in the general public is or if it can be prevented through lifestyle choices such as avoiding toxic substances. This is a subject of ongoing research.

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