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Mesothelioma is Caused by Exposure to Asbestos

Mesothelioma is primarily caused by asbestos exposure. Asbestos fibers cause irritation to the lining of organs and cause mesothelioma-related DNA damage. tumors.


Workers who work with asbestos carry the tiny fibers on their clothing, hair and tools, putting loved ones at risk of exposure through secondhand sources. Family members can also develop mesothelioma as a result of the chemicals in their spouse's clothing.

Asbestos

Asbestos is one of the minerals that occur naturally as bundles of tiny fibers. When asbestos is disturbed or broken up, these fibers can be released in the air and get inhaled. The fibers may be absorbed into the smallest airways, causing irritation to the lining of your lungs (the pleura). The irritation can cause cells to expand abnormally and grow into mesothelioma tumors. Mesothelioma also can affect other parts of the body with a similar lining including the peritoneum, the heart or testicles.

Medical records and other research have linked asbestos exposure to mesothelioma. Scientists aren't sure why certain people are more susceptible than others to mesothelioma. Researchers have discovered that the type of asbestos used as well as the much exposure a person had can impact their likelihood of developing this cancer.

The most common asbestos types that are associated with mesothelioma are chrysotile and amibole asbestos. They were used in the production of household and industrial products such as drywall, insulation and pipes cement, talcum powder and cement. People who are exposed to these substances at work have the most risk of developing mesothelioma. These workers usually worked in industries like construction, electrical work, shipbuilding or military work. Men are more likely than women to develop mesothelioma as they historically had more jobs that required exposure to asbestos.

When asbestos fibers get into the body, they stick to the organs like the lungs, chest wall as well as the intestines and abdomen. Mesothelium is a strong, durable material that can be resistant to damage. Asbestos fibers can get caught in the mesothelium and remain there for decades or even years. This can cause chronic irritation, which could eventually result in a mesothelioma tumour.

Mesothelioma, like all cancers is caused by DNA mutations which cause cells to multiply unchecked. This causes a tumor. Researchers have identified a number of factors that can increase a person's risk for mesothelioma, such as a family history of the disease as well as previous exposure to asbestos. Mesothelioma is a rare condition, can take decades to manifest. If you have a history of that you have, it is essential to consult your physician when you notice any symptoms or signs that worry you.

Erionite

Erionite is often found in close proximity to asbestos. It is also believed to cause mesothelioma - primarily pleural mesothelioma. It is also associated with cancer of the peritoneal region. Erionite belongs to the group of minerals referred to as zeolites. Electron microscopy has been used to perform several morphological studies on erionite. These studies show that fibers of erionite have a varying structure. They can be arranged in regular bundles, or as rod-like structures, based on the nanostructural characteristics of the erionite.

In a long-term study of the residents of villages exposed to the erionite mineral, Baris & Grandjean (2006) found that the death rate for mesothelioma to be significantly higher in these villages compared to a control village that was not exposed to erionite. Seventeen mesothelioma-related deaths as well as 119 mesothelioma-related peritoneal cases were documented in the villages exposed to erionite over a 23-year period. The authors concluded that the mesotheliomagenic potential of erionite was significantly higher than that of any other amphibole (antophyllite tremolite actinolite crocidolite as well as amosite), which are currently regulated under asbestos.

It is possible that the structural resemblance between asbestos and erionite could be the reason behind mesothelioma. In a study on rats, mesothelioma induced by erionite showed a similar cellular response like the rats exposed to asbestos. Mesothelioma that was caused by erionite had an increased Bax expression, as well as a decrease in Fas ligand.

The Department of Transportation in North Dakota is working with local counties as well as businesses to restrict the use of gravel containing Erionite. The department is continuing to monitor the erionite issue and inform people about it. Erionite is present in several areas of the United States, including Oregon, Idaho, and Arizona. A correct identification of erionite would allow researchers to examine samples from these regions with mesotheliomagenic erionite from Turkey. This information could help determine how common mesothelioma is across the U.S., and may be a way to improve screening and prevention strategies for those who are exposed to this substance. This is crucial because mesothelioma can develop between 30 and 60 years.

Silica

Silica, also known as quartz, is a popular industrial material that is found in the earth's crust. It is used in a variety of settings including construction, mining and agriculture. Inhaling silica may cause lung diseases like lung cancer and silicosis, depending on the type of work. Silica exposure also increases the risk of developing mesothelioma, which is a deadly and potentially fatal type of lung cancer that can develop in the mesothelium.

The International Agency for Research on Cancer (IARC) and the Occupational Safety & Health Administration have both classified inhaled crystalline silica as a human carcinogen. This is based on strong evidence that inhalation exposure to silica leads to lung cancer. The IARC has not yet acknowledged the role played by silica in an underlying cause of other cancers such as mesothelioma and bladder cancer.

Mesothelioma has been linked with exposure to two kinds of mineral fibers that are commonly used: asbestos and mineral wool. Mesothelioma is caused by aggrading and chronic irritation of the mesothelium. Inhaling other mineral fibers such as silica and mineral wool compounds this effect by further irritating the mesothelium. Mesothelioma is more commonly diagnosed in people over 45 because it takes a long time for mesothelioma to develop. It is most often diagnosed in men because they have more of a chance than women to have had jobs where they were exposed to asbestos and silica.

Asbestos, silica and other substances are known carcinogens to the lungs. Both the U.S. Environmental Protection Agency and the IARC recognize that mesothelioma, and other cancers, are correlated with these exposures. However, the fundamental mechanisms of these carcinogens' involvement in the development of other organs is not as well understood. The chemistry, physics, and physicochemical characteristics of inhaled silica and asbestos particles determine their removal from the lung and how they are transported to other organs like the bladder.

The authors of a recent study of a large sample have identified the relationship between asbestos and silica in the workplace exposure and the risk of bladder cancer using data from the National Enhanced Cancer Surveillance System in eight Canadian provinces. The cohort was exposed to various asbestos dusts and silica dusts, with the highest concentrations and frequency of exposure occurring in the mining, construction, masonry, quarrying and manufacturing industries.

Other Minerals

Minerals are solid substances that occur naturally on the Earth. They have specific chemical and physical properties, and a majority of them have an ordinary crystal structure. Examples include asbestos, which is a fibrous mineral, and barium. Both are soft metallic elements utilized in x ray technology, fireworks and rubber manufacturing. People exposed to these minerals at the workplace might be exposed to asbestos fibers in clothing and personal items that are then brought home and family members are able to take them in or swallow them.

Asbestos has been linked to mesothelioma that affects about 70% to 80% of all diagnosed cases. However, a small percentage of cases have been linked to exposure to non-asbestiform minerals. These minerals include erionite, other forms of silica and non-asbestiform granulerite used in mining operations.

Mesothelioma symptoms typically begin in the chest. They can cause breathing problems (dyspnea) as well as swelling and pain around the lungs and heart. The majority of the time, the disease develops in the pleura, which protects your diaphragm and the lung tissue. The disease may also manifest in the peritoneum, which covers your stomach and the intestinal tract. In mesothelioma caused by asbestos may spread to other areas of your body.

It can take between 20 and 20 years for pleural cancer to manifest after exposure to asbestos. This is why many affected people don't seek medical help until they experience significant symptoms such as persistent chest pain or an accumulation of lungs-related fluid.

The kind of treatment you receive for mesothelioma will depend on the severity of your disease and how far it has spread. For example, your doctor may recommend treatments to manage symptoms and help prolong life. This could include removing the lungs of fluid or using powerful painkillers to alleviate your discomfort.

In addition to treating your symptoms, your physician will typically prescribe medications to combat cancer cells or slow their growth. Chemotherapy is one of the most commonly used treatment options for pleural mesothelioma, and it is a treatment that can be used by itself or in combination with other treatments. Other treatments include surgery and radiation. Surgery can involve removing your lung or a portion of your diaphragm. Alternatively, it could be combined with radiation and chemotherapy.

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