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arrhythmia for an adult man. (t1/2 = 1.5 hr, V = 140 L,
desired Cpss = 2 mg/L.
Calculate Ko and loading dose.
2.A physician wants to administer an anesthetic agent
at a rate of 2 mg/hr by IV infusion. The elimination
rate constant is 0.1 hr-1 and the volume of distribution
(one compartment) is 10 L.
1. How much is the drug plasma concentration at the
steady state?
2. What loading dose should be recommended to reach
steady state immediately?
3. Calculate the drug concentration in the blood 2 hr
after infusion has been stopped after 6 hr
An adult male asthmatic patient (78 kg, 48 years old) with a history of
heavy smoking was given an IV infusion of theophylline at a rate of 0.75
mg/hr/Kg. (Theophylline T.W = 10-20 mg/L , t1/2 = 4 hr, Vd = 25L)
Calculate the followings:
1. Time the drug starts to show its action
2. If you think this time is long , show how can you
make the drug show its action within an hour?
3. Do you think this infusion rate is safe if left to steady
state?
4. So, how long will you allow this infusion to continue?
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