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In the early stages of the disease, tissue hemophagocytosis may be missed in bone marrow, and biopsies are difficult because of the severe coagulopathy. Other characteristics that are useful for the diagnosis of MAS include decreased NK-cell function, elevated ferritin levels, and extreme hyperferritinemia. However, these characteristics are not specific for MAS. The most common symptom is fever and weakness.
In patients, the disease can lead to death. While the most common clinical features of Mas are a prolonged fever, mucosal bleeding, hepatosplenomegaly, and lymphadenopathy, symptoms vary widely. Learn More of the disease can be characterised by multi-organ involvement, depressed level of consciousness, seizures, and coma. Other symptoms of MAS can include pulmonary infiltrates, respiratory distress, or pulmonary hemorrhage.
The underlying causes of MAS are not entirely known. Some studies suggest that the disease may be caused by abnormalities in the immune system. Mas Viral of MAS are triggered by certain infections and diseases. Some patients may also be sensitive to certain drugs, including NSAIDs and biologics. Other cases are unrelated to specific factors and are not triggered by any particular disease. In some instances, genetics may play a role.
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