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a. Efecte FAVORABILE: † capacitatea de aparare a organismului fat de infectii prin efect bactericid/bacteriostatic & antiviral ca urmare a:
• efectelor periferice ale pirogenilor endogeni -› stimularea imunitâtii NATIVE si
ADAPTATIVE
O eliberárii enzimelor lizozomale si autodigestia celulelor -* impiedicarea multiplicarii bacteriene/replicarii virale în celulele infectate
O inducerii sintezei proteinelor de soc termic (Heat Shock Proteins", HSP) -> 1 rãspunsul limfocitelor la antigenii microbieni
b. Efecte NEFAVORABILE:
• 1 cu 1 grad C a temperaturii necesitã ^ consumului celular de 02 cu cca. 13% -* accelerarea metabolismului ceca ce are o actiune nefavorabilã la pacientii cu afectiuni:
- cardiovasculare = prin suprasolicitarea cordului
- cerebrale = prin tulburari ale activitatii mentale (delir si stupor)
•O la copii apare riscul convulsiilor febrile
• la femeile gravide, în primul trimestru de sarcina, 1 episod febril cu temperatura ≥ 37 grade C -> dubleaza riscul aparitiei defectelor de tub neural la fat
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