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(Anti-PD1 MAB, immune checkpoint inhibitor)
Human IgG4 monoclonal antibody that selectively inhibits programmed cell death-1 activity by binding to PD-1 receptor to block the ligands PD-L1 and 2 from binding. Proliferation is therefore disrupted. T cells can attack the cancer
Uses:
Head/neck scc
Hodgkin Lymphoma
Melanoma
NSCLC
RCC
Urothelial carcinoma
SCLC
(2016 study suggested nivolumab can help tx advanced hcc)
Half life is 26.7 days, which is why pts receive it every 2 weeks for steady-state at 12 weeks (3mg/kg)
Fairly recent drug, discovery of AB was in 2014.
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