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Salamanders never have more than four toes on their front legs and five on their rear legs, but some species have fewer digits and others lack hind limbs. Their permeable skin usually makes them reliant on habitats in or near water or other cool, damp places. Some salamander species are fully aquatic throughout their lives, some take to the water intermittently, and others are entirely terrestrial as adults. Unique among vertebrates, they are capable of regenerating lost limbs, as well as other damaged parts of their bodies. Researchers hope to reverse engineer the remarkable regenerative processes for potential human medical applications, such as brain and spinal cord injury treatment or preventing harmful scarring during heart surgery recovery.[2] Members of the family Salamandridae are mostly known as newts and lack the costal grooves along the sides of their bodies typical of other groups. The skin of some species contains the powerful poison tetrodotoxin and these salamanders tend to be slow-moving and have bright warning coloration to advertise their toxicity. Salamanders typically lay eggs in water and have aquatic larvae, but great variation occurs in their lifecycles. In some species and some harsh environments, salamanders reproduce while still in the larval state.
In literature and legend, the salamander is associated with fire, being supposedly unharmed by the flames, while clothes made from its skins or 'wool' were believed to be incombustible. More plausibly, salamanders were said to be intensely poisonous. Despite this, salamander brandy, a drink prepared by dunking live salamanders in fermenting fruit juices, is reputed to have hallucinogenic and aphrodisiac properties.
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