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· General access denied, and sender access denied—the sender of the message does not have the required permissions necessary to complete delivery.
· You are trying to relay your mail through another SMTP server, and the server does not permit you to relay.
· The recipient may have mailbox delivery restrictions enabled. For example, if a recipient's mailbox delivery restriction is set to receive mail from a distribution list only, non-member's mail will be rejected and produce this error.
· New in Exchange 2003: An anonymous user attempted to send mail to recipients or distribution lists that accept mail only from an authenticated SMTP session.

A very common Exchange 2007 NDR, the cause is a permissions problem. For some reason the sender is not allowed to email this account.
Perhaps an anonymous user is trying to send mail to a distribution list.
Alternatively, a user may have a manually created email address that does not match a System Policy.
Check SMTP Virtual Server Access Tab. Try checking this box: Allow computers which successfully authenticate to relay.
Check the outgoing SMTP logs.
Check: Mailbox - <Mailboxname> - Properties - Mail Flow Settings - Message delivery restrictions.
Try disabling Windows-Integrated-Security. Instead allow only standard authorization on the SMTP receiver on the Exchange 2007 server.
Check Attachment filtering on the Edge server.
     
 
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