Notes

Behind the "elixir of immortality" in the popular scientific and technological circles, how long do we have to recover our youth?
PQQ (Pyrroloquinoline quinone),

In recent years, there has been a true story in the western life science community: Australian teenagers who grew up in northern Sydney were taken care of by their grandmother when they were young, and their grandparents and grandchildren have deep feelings. As the boy grew up, I couldn't bear to see my youthful and energetic grandmother stagger day by day, and was determined to find a way to fight aging. (William Shakespeare, Hamlet, life) after entering the brilliant MIT and Harvard University, he finally became a professor of genetics at Harvard University and discovered the important substance of world attention - nicotinamide mononucleotide. In 2018, the Renaissance, the first mature commercialization achievement of the material, was successful, triggering the competition for the rights of the rich.
The hero of this story is David Sinclair, director of Paul F. Glenn biomedical Center for aging, the world's most influential 100 people published by time magazine in 2014.
"Elixir of immortality" born with a golden spoon
Before Sinclair discovered the anti-aging effect of nicotinamide single nucleotide (riveror), the scientific community found a variety of substances that can prolong life, such as resveratrol and metformin, but they have not been verified in mammalian experiments. By 2014, Sinclair published his paper in the top academic journal Cell for the first time- Nicotinamide mononucleotide increases NAD (nicotinamide adenine dinucleotide), which is an important coenzyme that gradually decreases with the increase of human age. Nicotinamide mononucleotide can prolong the life span of humans and other mammals by 30%.
After Sinclair discovered the amazing effect of nicotinamide mononucleotide, his family became the first "mouse". Sinclair's wife Sandra ruckenhouse also received a doctorate in genetics from MIT. She observed an incredible reversal of youth when dogs took the molecule, and she began to take it. Sinclair's father had been taking the molecule for years. The 79 year old man is full of vitality. He not only took the non-profit biology work as his second career, but also insisted on high-intensity sports such as rafting and mountaineering. He said I didn't know what had happened. I haven't changed my way of life. There was no obvious improvement, but I didn't go downhill like my peers.
Studies have shown that nad not only plays an important role in human energy metabolism, but also is the only matrix of DNA repair enzyme PARP-1, which can improve the activity of deacetylase family called "longevity protein".
After Sinclair's breakthrough discovery, hundreds of subsequent papers pointed out the mechanism of - nicotinamide single nucleotide: maintaining the self-healing ability of cells by maintaining the content of NAD in vivo.
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