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Mitral kapak tam kapan- madığı için sol atriuma dönen kan, sol atrium ve sol ventriküllerin genişlemesine neden olur. Sol atrium, sistol sırasında aldığı büyük miktarda kana yanıt olarak dilate olur ve kanın sol atrium- da birikmesi sonucu yeterli kanı alamayan sol ventrikül, kalp debisini korumak için daha güçlü pompalama çabasına girerek hipertrofiye uğrar ve bu durum, sol ventrikül yetmezliğine yol açar (Bkz. Şekil 2.9). Zamanla, sol atriuma olan kan akımındaki artış sonucu sol atriumda yükselen basınç, geriye doğru akciğer venlerine ve arter- lerine yansır; sürekli yüksek basınç nedeniyle sağ kalp yetmezliği gelişebilir.
     
 
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