Notes

As Mani et al. point out, the time it takes different cell types to undergo apoptosis can vary markedly over an order of magnitude; it is difficult to estimate apoptotic rates in chronic disease situations when the rate of cell loss is continuous and very low level; the rate of loss in these situations may not be a pure exponential but may change over time; one needs to know the duration of apoptosis in a given cell type to determine the impact of a given apoptotic rate on the loss of cells in that tissue; and because of these uncertainties, the only way to evaluate the importance of apoptosis to a given disease process is to inhibit and/or accelerate the apoptosis and see what it does to the disease process.

farklı hücre türlerinin apoptoza uğraması için geçen süre, büyüklük sırasına göre belirgin farklılıklar gösterir. kronik hastalık durumlarında hücre kaybı oranı sürekli ve düşük seviyelerdeyken, apoptotik oranların tahmin edilmesi zordur. Bu gibi durumlarda kayıp oranı tam olarak üstel olmayabilir fakat zamanla değişebilir.

one needs to know the duration of apoptosis in a given cell type to determine the impact of a given apoptotic rate on the loss of cells in that tissue;