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<p class="p__0">However, management has actually made clear they will require additional capital prior to the start of the Phase III trials and we expect this to occur in the Q2/Q3 2019 timeframe and after extra analysis of Stage IIb data. As the Phase III trials advance over the next two years, we anticipate an acceleration in money burn.</p>
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<p class="p__1">and elsewhere. The low rates of success with current smoking cessation treatment and the high rates of negative effects for varenicline and bupropion create an unmet need that cytisinicline might partly attend to. Cytisinicline may be able to show outstanding stopped rates when combined with behavioral assistance and a lower side impact profile compared to current market leader varenicline to penetrate a medication market of near $5 billion.</p>
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<p class="p__2">Over one billion or about 20% of people smoke around the world and almost 40 million or 15% smoke in the United States. The CDC estimates that about 70% of these individuals wish to give up and over 50% have actually tried to stop in the United States. However, among Also Found Here in tobacco, nicotine, is extremely addicting, making the effort to stop smoking very challenging.</p>
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<p class="p__3">The CDC also approximates cigarette smoking reduces life expectancy by about 13 years for men and 14 years for females, which is in addition to a lower quality of life throughout the later years. One popular technique to stop cigarette smoking recently is making use of e-cigarettes, or vaping, which deliver liquid nicotine into a mist or vapor which is breathed in.</p>
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