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PQQ:Pyrroloquinoline quinone:NMN:Nicotinamide Mononucleotide:Phosphatidylserine:Anti-aging supplements
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Research from the University of Washington School of medicine has proved that natural compounds that delay aging and improve metabolic health in mice have clinical effects related to humans.
A small clinical trial of premenopausal women with prediabetes shows that compound nicotinamide mononucleotide (NMN) improves the ability of skeletal muscle to absorb glucose, which is usually abnormal in obesity, prediabetes or type two diabetes. NMN also improved muscle structure and expression of related genes. However, this treatment can not reduce blood glucose and blood pressure, improve blood lipid, improve liver insulin sensitivity, reduce liver fat and inflammatory circulating markers.
This study, recently published online in science, is the first randomized clinical trial to study the effects of NMN on human metabolism. Among the women participating in the study, 13 took 250 mg NMN orally every day for 10 weeks. During the same period, another 12 people took inactive placebo every day.
The researchers conducted a clinical trial on 25 postmenopausal women with prediabetes symptoms (blood sugar above normal level, but not diagnosed as diabetes). Previous studies on mice have shown that NMN has the greatest effect on female mice.
Nm participates in the synthesis of nicotinamide adenine dinucleotide (NAD), which is an important compound produced by all cells. This compound plays an important role in keeping animals healthy. In many animals, including humans, nad levels decrease with age. The compound has been shown to cause various problems related to aging, including insulin resistance in mice. NMN supplementation to animals can alleviate and improve the functional decline of many age-related body tissues.
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