Notes

How powerful is jd.com's "elixir of immortality" that angers health food manufacturers?
Hemorrhoids

In recent years, there has been a true story in the western life science community:
Australian boys who grew up in northern Sydney have been taken care of by their grandma since childhood. Grandpa and grandma are very loving.
When the boy grew up, I couldn't bear to see my grandmother, who was once full of youth and vitality, staggering day by day, determined to find a way to fight aging.
After entering the brilliant Massachusetts Institute of technology and Harvard University, he finally became a professor of genetics at Harvard University and discovered the important substance that attracted worldwide attention - nicotinamide mononucleotide. In 2018, the Renaissance, the first mature commercialization achievement of the material, succeeded, triggering competition in the rich circle.
The hero of this story is David Sinclair, who is the director of Paul f Glenn biomedical Center for aging, the world's most influential 100 people published by time magazine in 2014.
"Elixir of immortality" born with a golden spoon
Before Sinclair discovered the anti-aging effect of nicotinamide mononucleotide (riveror), the scientific community found several substances that may prolong life, such as resveratrol and metformin, but they have not been verified in mammalian experiments.
By 2014, Sinclair published a paper in the top academic journal Cell for the first time, which confirmed that - nicotinamide single nucleotide will increase the important coenzyme NAD (nicotinamide adenine dinucleotide) that gradually decreases with age in the human body. Subsequent experiments proved that the life span of mammals similar to humans can be extended by more than 30%, which instantly became a hot spot in the scientific community.
After Sinclair discovered the amazing effect of nicotinamide single nucleotide, his family became the first "mouse". Sinclair's wife Sandra rukenhouse also received a doctorate in genetics from MIT. When she observed an incredible reversal of rejuvenation when dogs took the molecule, she began to take it.
Sinclair's father had been taking the molecule for years. The 79 year old man is full of vitality. He not only took the non-profit biology work as his second career, but also insisted on high-intensity sports such as rafting and mountaineering.
'I don't know what has changed,' he said. I haven't changed my way of life. Although I can't see obvious improvement, I didn't go downhill like my peers.
Studies have shown that nad not only plays an important role in human energy metabolism, but also is the only substrate of DNA repair enzyme PARP-1. It can improve the activity of deacetylase family called "longevity protein", which is the key to activate cellular DNA repair function
Unfortunately, the ability of NAD synthesis in the body drops rapidly in middle age, the ability of cell repair decreases, and aging accelerates.
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