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Lymphatic absorption of oxidized cholesterol in rats

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<p class="p__0">The objective of the current study was to figure out whether oxidized cholesterol in the diet plan speeds up atherosclerosis in low density lipoprotein receptor- (LDLR) and apolipoprotein E- (apo E) deficient mice. Mice were fed either a control diet plan or a diet plan containing oxidized cholesterol. For LDLR-deficient mice, the control diet plan included routine mouse chow to which 1. 0% cholesterol was included. The oxidized diet plan was similar to the control diet other than that 5% of the added cholesterol was oxidized. In apo E-deficient mice, the control diet plan contained 0. 15% cholesterol, whereas in the oxidized diet, 5% of the added cholesterol was oxidized.</p>
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<p class="p__1">In mice fed the oxidized-cholesterol diet plans, the levels of oxidized cholesterol in sera were increased. At the end of the experiment, aortas were gotten rid of and atherosclerosis was evaluated. We found that in LDLR-deficient mice, feeding of an oxidized-cholesterol diet resulted in a 32% boost in fatty streak lesions (15. 93+/ -1. 59% versus 21. 00+/ -1. 38%, P.</p>
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