Notes

Registration Certificate Owner:
Moscow Endocrine Plant, FSUE (Russia)
ATX code: G03GA01 (Chorionic Gonadotropin)
Active substance: Gonadotropin Chorionic (Chorionic Gonadotrophin)
Rec.INN Registered V.
Dosage form
[The drug is released by recipe] Gonadotropin chorionic
Lyophilisate d / quotation. P-RA D / V / M introduction 1500 me: FL. 5 pieces. in a set with solvent
Reg. No: LS-002469 dated 04.05.12 - indefinitely
Release form, packaging and composition of gonadotropin chorionic
The lyophilisate for the preparation of the solution for the introduction of 1 PL.
Human chorionic gonadotropin 1500

Solvent: sodium chloride rr d / and 0.9% - 1 ml.

1500 me - bottles (5) complete with solvent (AMP 5 pcs.) - Cardboard packs.
Clinical and Pharmacological Group: Recombinant Human Chorionic Gonadotropin
Pharmaco-therapeutic Group: Lutinizing agent
pharmachologic effect

Gonadotropic hormone. It is produced by a person's placenta and stand out in the urine where it can be extracted and cleaned. Stimulates the production of progesterone with a yellow body and maintains the development of the placenta. It has a gonadotropic effect, mainly luteientizing.

In women, the drug causes ovulation and stimulates the synthesis of estrogen and progesterone. Men - stimulates spermatogenesis and genital steroid products.
Pharmacokinetics

After the introduction, the introduction is well absorbed. T1 / 2 is 8 hours.

It is believed that before removing with urine, chorionic gonadotropin is modified in the body, because Its T1 / 2, measured by the immunological method, significantly exceeds this indicator, determined by biological activity.
Indications of active substances drug gonadotropin chorionic.
For women: ovarian dysfunction (annevulatory), amenorrhea; induction of ovulation with infertility due to anointing or impaired ripening of follicles; maintaining the yellow body phase; Preparation of follicles to puncture in programs of controlled overstimulation of ovaries (for auxiliary reproductive technologies).

For boys and men: the delay in puberty, due to the insufficiency of the gonadotropic function of the pituitary Cryptorchism, not due to anatomical obstruction; deficiency of spermatogenesis, oligo-asthenospermia, azoospermia; When conducting a differential diagnostic test of anhorism and cryptorchism in boys; When conducting a functional test of leildig to assess the function of the testicles in hypogonadotropic hypogonadism before the start of long-term stimulating treatment.
Open List of ICB-10 Codes
Dosing mode
The method of application and the dosing mode of a particular drug depend on its form of release and other factors. The optimal dosing mode is determined by the doctor. It should be strictly observed the correspondence of the dosage form of a particular preparation to the use and dosing regime.
Individual, depending on the testimony and treatment regimen.
Side effect

From the endocrine system in women: the development of the syndrome of the ovarian hyperstimulation syndrome, accompanied by the development of the ovarian cyst, with the danger of their gap, ascite, hydrotorax and the danger of thromboembolism.

From the endocrine system of boys and men: temporary reversible increase in mammary glands, prostate gland, water and electrolyte delay, ordinary acne; Boys have changed behaviors similar to those observed during the first phase of puberty, which take place after the end of treatment.
Contraindications for use

Hormone-dependent malignant tumors of genital organs and breast (ovarian cancer, uterine cancer, breast cancer in women); Androgen-dependent tumors (prostate cancer, breast cancer, testicular tumor); the presence of a cyst or an increase in the size of the ovaries that are not related to the ovarian polycystic syndrome; bleeding or bleeding from vagina unclear etiology; Ectopic pregnancy in history (3 months before treatment); primary ovarian failure; Innomalia development of genital organs in women incompatible with the normal course of pregnancy; Myoma uterus incompatible with pregnancy; menopause; The states associated with the uncomplication of the egg in the scrotum (groin, surgical operations in the field of groin, ectopia of the egg); organic lesions of the central nervous system (including pituitary tumors, hypothalamus); thrombophlebitis deep veins; hypothyroidism; adrenal insufficiency; hyperprolactinemia; pregnancy, breastfeeding period; Children's age up to 3 years.

Carefully

IHD, chronic heart failure, epilepsy, migraine (including history), chronic renal failure, arterial hypertension, in women with risk factors for thrombosis; Boys in the prepubertal period.
Application in pregnancy and breastfeeding

Application is contraindicated during pregnancy and during breastfeeding period.
Application with violations of the kidney function
With caution to apply in disruption of the kidney function.
Application in children
Contraindicated application in children under 3 years old.
Application in elderly patients

Contraindicated use with menopause.
special instructions

A long-term use is not recommended due to the possible formation of antibodies that reduce the effectiveness of treatment.

In the event of the development of ovarian hyperstimulation syndrome, it should be discontinued.