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Both agents block the aldosterone receptor, but spironolactone has progestogenic and antiandrogenic activities, effects that are minimized in eplerenone. So far, the prevalence of adverse impacts with eplerenone was slightly lower than with spironolactone. Objective: To review the pharmacology, pharmacokinetics, clinical efficacy, and safety of eplerenone, a new selective aldosterone blocker. Information synthesis: Eplerenone is a selective aldosterone blocker. Animal studies with eplerenone have shown a favorable role in aldosterone antagonism in the treatment of hypertension, diabetes, heart failure, myocardial infarction, renal dysfunction, and atherosclerosis. The drug may be approved for therapy of hypertension in 2002. Additional studies are ongoing that may offer advice on other clinical applications for this medicine. In humans, eplerenone appears to be successful for the treatment of hypertension.
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