Notes

Circulation ! to deliver things. And to flush out excess

Acinity

High rate of flow > cuz they release hormones (table of variations ...)

Flow is a factor of pressure ?

Dialate > flow up / resistance down
INVERSE PROPORTION

Low O2 > like in mountain high altitude > red face because vasodilation VESSELS GO TO FACE

increase flow
——————

Arterial blood [oxygenated]

when tissue metabolism is UP > Vasodilator (adenosine !!! Comes from? )
molecules that Induce relaxation of muscle cells ?

*check memory booster

- who takes anti histamines?

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prevent toxic ischamic death ::::
????

No O2 enuff to muscle cells = no ATP reduction = no contraction of cells = relaxation

U need atp at sphincters tockeep contrwcted ?


Contract relax depending on TISSUES need
not all capillaries are open at the same time

sometimes you don’t need to open them all just open the few closed ones. And then replenish blud flow?

but IF fails ??

Vaso motion rlx cntction

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Vitamins > involved in atp production (we DONT Synthesizer vitamins)

Vit B Löw

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Lese O2 > vasodilators released >
Less O2 = ACTIVE hyperemia

bring more blud = sufficient for tissues

///
Reactive hyperemia ???if you have oclusion???

—————-BOTH INDUCE VASODILATION

compare change in blood flow locally , acute (fractions of second can change(and that’s reversible?))and long term(not much change in flow)

u need more open more

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increase in blud Pressure (P) it’s sense at the walls of blood vessels > YOU have what(endethelial) cells then smooth muscle cells then they have to relax to accommodate blud p

problem. older = more stiff vessels

//

Endethelial under constant P from blood volume = stress UP = release gas nitric oxide
activated an enzyme WHERE

WHAT )release of GMP = relaxation

Myogenic response

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Viagra = parasympathetic arterioles Problem > more blood bigger size

Drug viagara

(If Sidenafi Inhibits cGMP relaxation more time wreciton more time£
Cyclic GMP of degraded no flow no erection

it can block artery and heart attac

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if endothelium damage > inside endthlil cells > powerful vaso constrictor
*?
haemorrhage can stop ?
———-
This was acute regulation (only gives around 3 quarters of what tissue is demanding , can’t reach optimal level 100% demand of tissue needs)
Need more blood vessels , capillaries


Now...
LONG TERM

new tube after a while will be released by vasodilator? And meets another tube

*O2 the important regulator ?

**defense against ischemia?? More capillaries after cut what

Picture slide


Premature babies > O2 therapy , blood vessels get used to UP levels then removed from box blood vessels dilate so much because they need more o2 and they can burst , if it’s very elaborate it could lead to??