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可活化自然殺手細胞的毒殺作用及巨噬細胞活性，同時透過自體分泌產生更多IL-2
(B)IL-10(介白質-10)產自TH2細胞，會抑制IFN-y及IL-2的抗炎作用，
且會降低MHC-II活性，並會抑制巨噬細胞產生IL-1與IL-6.
這2激素一減少，T細胞活性就會降低
(C)T細胞活化須由抗原呈現細胞(APC)上的二級MHC將抗原呈現給T細胞，
並將其與TCR結合，形成MHC-抗原-TCR三元結構，以此傳遞第1訊號，
再藉由T-CELL上的CD-28與APC上的B7-1(CD80)/B7-2(CD86)結合，
傳遞第2訊號，才能活化T細胞
(D)CD-28+CD80/CD-86的組合(第二組訊號)，又稱共激分子
若缺乏此分子，而單純只有MHC-抗原-TCR，T細胞便不活化
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