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A high-dose 24-hour tranexamic acidity infusion for the treatment of considerable stomach hemorrhaging: HALT-IT RCT.
After successful implementation for more than 6 decades by the oil and gas industry, hydraulic fracturing remains the pioneer well stimulation method to date. Polymers are one of the additives in fracturing fluids that play a significant role. Polymers are used as friction reducers and viscosifiers to provide a transport medium for proppants in fracturing fluids. There are many polymer-based fracturing fluid systems, but choosing the most appropriate type and system depends on the type of application and a wide range of parameters. Currently, there is no complete review study that gives a reference and hence a perspective for researchers on the use of polymers in hydraulic fracturing. This paper summarizes the published literature on polymers used in fracturing fluids and discusses the current research issues, efforts, and trends in the field, aiming to provide an overview of the polymer applications in slick-water and cross-linked gel systems. The mechanism and limitation of polymer use such as polymer degradation, fracture conductivity reduction, and polymer adsorption are also reviewed in this paper. selleck chemicals llc The reviewed literature suggested that polymers are important additives in fracturing fluids not only to provide adequate transportation of proppants but also to determine the width of the fracture whereby higher viscosities yield wider fractures. The development of synthetic polymers and associative polymers in fracturing fluids showed a remarkable potential to improve the stability of fracturing fluids in unconventional reservoirs under reservoir conditions, which makes it an interesting topic for future studies.Evaluation of the acidic characteristics of a jet fuel, especially for the total acid number (TAN), is of great significance to ensure flight safety. Methylbenzene is commonly used as the titration solvent; however, it is poisonous and harmful to the environment. It is highly desirable to develop an alternative solvent for methylbenzene to extract the acidic compounds from the jet fuel during the determination of the TAN. Here, we develop a desirable alternative solvent of a mixed ethanol-water solution with the volume ratio of ethanol to water of 991, which exhibits a value of TAN similar to that of the solvent of methylbenzene in potentiometric titration and acid-base titration methods. The TAN value derived from the different titration solvents was in the order of 2.96 μg KOH g-1 (V cyclohexane/V isopropanol/V water = 100991) > 2.68 μg KOH g-1 (V methylbenzene/V isopropanol/V water = 100991) ≈ 2.6 μg KOH g-1 (V absolute ethanol/V water = 991) > 2.34 μg KOH g-1 (V isopropanol/V water = 991). The current report presents a nontoxic and eco-friendly alternative solvent for methylbenzene, which may open up an avenue for evaluating the TAN of jet fuels.The solar/chlorine system has been proposed as a novel advanced oxidation process (AOP) for efficient pollutant degradation and water disinfection by producing a series of reactive species including hydroxyl radicals (HO•), chlorine radicals (Cl•), and so forth. In this study, the role of natural organic matter (NOM) in the photolysis of free available chlorine (FAC) and the formation of HO• and Cl• in the solar/chlorine system was investigated employing nitrobenzene and benzoic acid as selective chemical probes. The decay rate of FAC was significantly accelerated in the presence of NOM at pH 5.5 under simulated solar irradiation, likely due to the photoreaction between FAC and the photoexcited NOM. The decay rate of FAC increased upon increasing the electron-donating capacity of NOM, which indicated that phenolic components play a significant role in the photodegradation of FAC. This acceleration mechanism was further verified using 4-nitrophenol as a model phenolic compound. NOM promoted Cl• formation and quenched HO• in the solar/chlorine system. The proposed reaction mechanism included the reaction of excited singlet phenolic compounds in NOM with FAC, which yielded Cl•. This study provides a useful insight into future applications for using the solar/chlorine system as a novel AOP for wastewater treatment or disinfection.Green synthesis of nanoparticles plays an important role in their efficient therapeutic effects in various biomedical applications. Here, we prepared gold nano bioconjugates (GNBCs) from the ethyl acetate fraction of onion peels and investigated their anti-inflammatory activity in lipopolysaccharide-stimulated RAW 264.7 macrophages. The GNBCs were characterized by UV-visible spectroscopy, dynamic light scattering, and transmission electron microscopy. Comparative studies have been conducted among GNBCs, fractionate alone [onion peel drug (OPD)], and the standard drug dexamethasone in various anti-inflammatory assays. It was observed that GNBCs showed comparatively good therapeutic efficacy than the fractionate alone. At the lowest 10 μg/mL concentration, the GNBC and OPD exhibited 70.86 and 91.98% of reactive oxygen species production, 10.88 and 20.97 ng/μL of nitrite production, 337 and 378 pg/mL of TNF-α production, 27.1 and 30.64 pg/mL of IL-6 production, respectively, by maintaining a satisfactory cell viability. Moreover, to understand the mechanistic pathway of GNBCs in their entry into the macrophages, their localization, and duration, uptake studies have been performed where a caveolar-mediated endocytosis pathway is found to be prominent. Hence, this study will lead to the development of cheap, green synthesis of nano bioconjugates and their role in inflammation.In recent years, flexible and stretchable sensors have been a subject of intensive research to replace the traditional sensors made up of rigid metals and semiconductors. In this paper, a piezoresistive airflow sensor was designed and tested to measure the speed of air inside a pipe. Graphene/polyvinylidene fluoride nanocomposite films were prepared using a solvent-cast technique on a flexible polyethylene substrate as a piezoresistive material. Three different solutions were studied as a function of graphene concentration. The microstructure of the nanocomposite was characterized by X-ray diffraction, scanning electron microscopy, and optical microscopy. The effect of temperature on electrical conductivity was investigated by heating and cooling the sample between the room temperature and 150 °C. The stretchability of the nanocomposite film was studied with a tensile test, and the same procedure was employed to determine the breakdown point of the electrical conductivity. The sensor response was measured in terms of the resistance change caused by air pressure and found to increase with the concentration of graphene in the composite. The sensing characteristics were simulated using the COMSOL Multiphysics software, and the modeled data were compared favorably with the experimental result. The sensitivity of the sensor was found to be 1.21% kPa-1 in the range of 0-2.7 kPa. This piezoelectric sensor possesses unique characteristics such as being lightweight, flexible, and exhibiting fast response; hence, it can have potential applications in various sectors such as ventilators, commercial HVAC, and automotive industries.Engineering and synthesis of novel materials are vital for removing emerging pollutants, such as pharmaceuticals from contaminated water. In this study, a magnetic carbon nanofiber (MCF) fabricated from bacterial cellulose was tested for the adsorption of diclofenac from water. The physical and chemical properties of the synthesized adsorbent were examined by field emission scanning electron microscopy (FESEM), field emission transmission electron microscopy (FETEM), X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET) analysis, energy-dispersive X-ray spectroscopy (EDS), a vibrating sample magnetometer (VSM), Raman spectroscopy, and Fourier transform infrared (FTIR) spectroscopy. The characterization results showed that the MCF is a carbon nanofiber with a three-dimensional interconnect network, forming a porous material (mesopores and macropores) with a specific surface area of 222.3 m2/g. The removal of diclofenac (10 mg/L) by the MCF (0.75 g/L) was efficient (93.2%) and fast (in 20 min). According to the Langmuir isotherm model fitting, the maximum adsorption capacity of the MCF was 43.56 mg/g. Moreover, continuous adsorption of diclofenac onto MCF was investigated in a fixed-bed column, and the maximum adsorption capacity was found to be 67 mg/g. The finding of this research revealed that the MCF could be a promising adsorbent used to remove diclofenac from water, while it can be easily recovered by magnetic separation.Thermally activated delayed fluorescence (TADF) materials enable organic light-emitting devices (OLEDs) to exhibit high external quantum efficiency (EQE), as they can fully utilize singlets and triplets. Despite the high theoretical limit in EQE of TADF OLEDs, the reported values of EQE in the literature vary a lot. Hence, it is critical to quantify the effects of the factors on device EQE based on data-driven approaches. Herein, we use machine learning (ML) algorithms to map the relationship between the material/device structural factors and the EQE. We established the dataset from a variety of experimental reports. Four algorithms are employed, among which the neural network performs best in predicting the EQE. The root-mean-square errors are 1.96 and 3.39% for the training and test sets. Based on the correlation and the feature importance studies, key factors governing the device EQE are screened out. These results provide essential guidance for material screening and experimental device optimization of TADF OLEDs.In this work, a photocatalytic process was carried out to recover gold (Au) from the simulated non-cyanide plating bath solution. Effects of semiconductor types (TiO2, WO3, Nb2O3, CeO2, and Bi2O3), initial pH of the solution (3-10), and type of complexing agents (Na2S2O3 and Na2SO3) and their concentrations (1-4 mM each) on Au recovery were explored. Among all employed semiconductors, TiO2 exhibited the highest photocatalytic activity to recover Au from the simulated spent plating bath solution both in the absence and presence of complexing agents, in which Au was completely recovered within 15 min at a pH of 6.5. The presence of complexing agents remarkably affected the size of deposited Au on the TiO2 surface, the localized surface plasmon effect (LSPR) behavior, and the valence band (VB) edge position of the obtained Au/TiO2, without a significant change in the textural properties or the band gap energy. The photocatalytic activity of the obtained Au/TiO2 tested via two photocatalytic processes depended on the common reduction mechanism rather than the textural or optical properties. As a result, the Au/TiO2 NPs obtained from the proposed recovery process are recommended for use as a photocatalyst for the reactions occurring at the conduction band rather than at the valence band. Notably, they exhibited good stability after the fifth photocatalytic cycle for Au recovery from the actual cyanide plating bath solution.Coalbed methane is a type of high-quality clean energy. The development of coalbed methane helps protect the living environment of humans and solves the safety problems in coal mining. However, a large amount of pulverized coal is generated after coalbed methane fracturing, which reduces the production of coalbed methane. Reduction of pulverized coal generation and prevention of pulverized coal migration are important for the development of coalbed methane. This study innovatively mixed calcium sulfoaluminate particles and sand to create a new fracturing proppant. The new proppant was carried by the fracturing fluid into the formation cracks and cured to form a permeable cement stone with a certain compressive strength and permeability at formation temperature and pressure. The permeability and compressive strength of the permeable cement stone were measured at different curing temperatures. Results showed that when the compressive strength of the permeable cement stone was 5.46 MPa, the gas and water permeabilities could reach 2.
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