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NFAT signaling inside individual mesenchymal stromal tissues impacts extracellular matrix upgrading and also antifungal defense replies.
In this paper, a linguistic steganalysis method based on two-level cascaded convolutional neural networks (CNNs) is proposed to improve the system's ability to detect stego texts, which are generated via synonym substitutions. The first-level network, sentence-level CNN, consists of one convolutional layer with multiple convolutional kernels in different window sizes, one pooling layer to deal with variable sentence lengths, and one fully connected layer with dropout as well as a softmax output, such that two final steganographic features are obtained for each sentence. The unmodified and modified sentences, along with their words, are represented in the form of pre-trained dense word embeddings, which serve as the input of the network. Sentence-level CNN provides the representation of a sentence, and can thus be utilized to predict whether a sentence is unmodified or has been modified by synonym substitutions. In the second level, a text-level CNN exploits the predicted representations of sentences obtained from the sentence-level CNN to determine whether the detected text is a stego text or cover text. Experimental results indicate that the proposed sentence-level CNN can effectively extract sentence features for sentence-level steganalysis tasks and reaches an average accuracy of 82.245%. Moreover, the proposed steganalysis method achieves greatly improved detection performance when distinguishing stego texts from cover texts.Cross-project defect prediction (CPDP) aims to predict the defect proneness of target project with the defect data of source project. Existing CPDP methods are based on the assumption that source and target projects should have the same metrics. Heterogeneous cross-project defect prediction (HCPDP) builds a prediction model using heterogeneous source and target projects. Existing HCPDP methods just focus on one source project or multiple source projects with the same metrics. These methods limit the scope of getting the source project. In this paper, we propose Heterogeneous Defect Prediction with Multiple source projects (HDPM) which can use multiple heterogeneous source projects for defect prediction. HDPM based on transfer learning which can learn knowledge from one domain and use it to help with other domain. HDPM constructs a projective matrix between heterogeneous source and target projects to make the distributions of source and target projects similar. We conduct experiments on 14 projects from four public datasets and the results show that HDPM can achieve better performance compared with existing CPDP methods, and outperforms or is comparable to within-project defect prediction method. The use of multiple heterogeneous source projects for defect prediction can effectively extend the data acquisition range of defect prediction and make software defect prediction better applied to software engineering.Within the well-known framework of financial portfolio optimization, we analyze the existing relationships between the condition of arbitrage and the utility maximization in presence of insider information. We assume that, since the initial time, the information flow is altered by adding the knowledge of an additional random variable including future information. In this context we study the utility maximization problem under the logarithmic and the Constant Relative Risk Aversion (CRRA) utilities, with and without the restriction of no temporary-bankruptcy. In particular, we show that the value of the insider information may be bounded while the arbitrage condition holds and we prove that the insider information does not always imply arbitrage for the insider by providing an explicit example.In last decades, the interest to solve dynamic combinatorial optimization problems has increased. Metaheuristics have been used to find good solutions in a reasonably low time, and the use of self-adaptive strategies has increased considerably due to these kind of mechanism proved to be a good alternative to improve performance in these algorithms. On this research, the performance of a genetic algorithm is improved through a self-adaptive mechanism to solve dynamic combinatorial problems 3-SAT, One-Max and TSP, using the genotype-phenotype mapping strategy and probabilistic distributions to define parameters in the algorithm. The mechanism demonstrates the capability to adapt algorithms in dynamic environments.We propose a multi-group, multi-scale mathematical model to investigate the betweenhost and within-host dynamics of cholera. At the between-host level, we divide the total population into a number of host groups with different characteristics representing spatial heterogeneity. Our model incorporates the dual transmission pathways that include both the environment-to-human and human-to-human transmission routes. Decitabine molecular weight At the within-host level, our model describes the interaction among the pathogenic bacteria, viruses, and host immune response. For each host group, we couple the between-host disease transmission and within-host pathogen dynamics at different time scales. Our study thus integrates multi-scale modeling and multi-group modeling into one single framework. We describe the general modeling framework and demonstrate it through two specific and biologically important cases. We conduct detailed analysis for each case and obtain threshold results regarding the multi-scale dynamics of cholera in a spatially heterogeneous environment. In particular, we find that the between-host reproduction number is shaped by the collection of the disease risk factors from all the individual host groups. Our findings highlight the importance of a whole-population approach for cholera prevention and intervention.Chronic eye diseases are the main cause of vision loss among adults. Among these, retinal degenerative diseases affect millions of people globally, causing permanent loss of cells and organ dysfunction. Despite recent progress in developing stem cell therapies for retinal diseases, methods for delivery remain an area of intense research. Aerosol technology is a promising technique with the potential to spray cells evenly and directly across the retinal surface, promoting cell attachment and survival. Here we implement mathematical modelling of the spraying process to develop organ-specific spraying parameters in this therapeutic scenario. Firstly, we characterise the rheological parameters for a typical hydrogel used for spraying cells. These parameters are then integrated into a 3D computational model of an adult human eye under realistic surgical conditions. Simulation results provide quantitative relationships between the volume flow rate of the cell-laden hydrogel, external pressure needed for aerosolization, angle of the spraying, and properties of the cell delivery.
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